TargetMol

KRAS inhibitor-9

Product Code:
 
TAR-T8756
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8756-1mg1mg£115.00
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TAR-T8756-2mg2mg£133.00
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TAR-T8756-5mg5mg£168.00
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TAR-T8756-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T8756-10mg10mg£230.00
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TAR-T8756-25mg25mg£369.00
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TAR-T8756-50mg50mg£503.00
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TAR-T8756-100mg100mg£625.00
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This product comes from: United States.
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Further Information

Bioactivity:
KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells
CAS:
300809-71-6
Formula:
C13H9ClN2S2
Molecular Weight:
292.8
Pathway:
MAPK; GPCR/G Protein; Apoptosis
Purity:
0.9994
SMILES:
Nc1ccc(Sc2nc3ccccc3s2)c(Cl)c1
Target:
Apoptosis; Ras

References

Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.