TargetMol

CP 424174

Product Code:
 
TAR-T8828
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8828-1mg1mg£111.00
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TAR-T8828-2mg2mg£128.00
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TAR-T8828-5mg5mg£151.00
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TAR-T8828-1mL1 mL * 10 mM (in DMSO)£179.00
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TAR-T8828-10mg10mg£193.00
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TAR-T8828-25mg25mg£290.00
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TAR-T8828-50mg50mg£399.00
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TAR-T8828-100mg100mg£549.00
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Further Information

Bioactivity:
CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
CAS:
210825-31-3
Formula:
C22H29ClN2O4S
Molecular Weight:
452.99
Pathway:
Immunology/Inflammation
Purity:
1
SMILES:
CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(c1)C(C)(C)O
Target:
IL Receptor

References

Perregaux D G , Mcniff P , Laliberte R , et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.[J]. Journal of Pharmacology & Experimental Therapeutics, 2001, 299(1):187.