TargetMol

JNJ-63576253 free base

Product Code:
 
TAR-T8933
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8933-1mg1mg£103.00
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TAR-T8933-2mg2mg£115.00
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TAR-T8933-5mg5mg£136.00
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TAR-T8933-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T8933-10mg10mg£181.00
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TAR-T8933-25mg25mg£298.00
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TAR-T8933-50mg50mg£434.00
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TAR-T8933-100mg100mg£605.00
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This product comes from: United States.
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Further Information

Bioactivity:
JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
CAS:
2110426-27-0
Formula:
C23H21F3N6O2S
Molecular Weight:
502.52
Pathway:
Endocrinology/Hormones
Purity:
0.9832
SMILES:
FC(F)(F)c1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCNCC3)nc2)C2(CCC2)C1=O
Target:
Androgen Receptor

References

Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 28;64(2):909-924.