TargetMol

ICA-105574

Product Code:
 
TAR-T9009
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9009-1mg1mg£99.00
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TAR-T9009-5mg5mg£138.00
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TAR-T9009-1mL1 mL * 10 mM (in DMSO)£173.00
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TAR-T9009-10mg10mg£189.00
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TAR-T9009-25mg25mg£322.00
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TAR-T9009-50mg50mg£466.00
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TAR-T9009-100mg100mg£651.00
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TAR-T9009-500mg500mg£1,291.00
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This product comes from: United States.
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Further Information

Bioactivity:
ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.
CAS:
316146-57-3
Formula:
C19H14N2O4
Molecular Weight:
334.331
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling
Purity:
0.9977
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Target:
HER

References

Meng J , Shi C , Li L , et al. Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization[J]. European Journal of Pharmacology, 2013, 718(1-3):87-97. Zangerl-Plessl E M , Berger M , Drescher M , et al. Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574[J]. Journal of Chemical Information and Modeling, 2019, XXXX(XXX).