TargetMol

SKI-178

Product Code:
 
TAR-T9014
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9014-2mg2mg£103.00
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TAR-T9014-5mg5mg£124.00
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TAR-T9014-1mL1 mL * 10 mM (in DMSO)£129.00
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TAR-T9014-10mg10mg£164.00
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TAR-T9014-25mg25mg£252.00
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TAR-T9014-50mg50mg£362.00
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TAR-T9014-100mg100mg£510.00
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TAR-T9014-500mg500mg£1,010.00
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Further Information

Bioactivity:
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
CAS:
1259484-97-3
Formula:
C21H22N4O4
Molecular Weight:
394.431
Pathway:
GPCR/G Protein; Apoptosis
Purity:
0.992
SMILES:
COc1ccc(cc1)-c1cc([nH]n1)C(=O)NN=C(/C)c1ccc(OC)c(OC)c1
Target:
Apoptosis; S1P Receptor

References

Hengst JA, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017;3(4):109-121. Dick TE, et al. The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J Pharmacol Exp Ther. 2015;352(3):494-508.