TargetMol

HM-30181 mesylate monohydrate

Product Code:
 
TAR-T9173
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9173-1mg1mg£121.00
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TAR-T9173-2mg2mg£143.00
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TAR-T9173-5mg5mg£173.00
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TAR-T9173-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-T9173-10mg10mg£236.00
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TAR-T9173-25mg25mg£346.00
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TAR-T9173-50mg50mg£466.00
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TAR-T9173-100mg100mg£645.00
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TAR-T9173-200mg200mg£816.00
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TAR-T9173-500mg500mg£1,187.00
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  • Further Information
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Further Information

Bioactivity:
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
CAS:
2097125-58-9
Formula:
C39H42N6O11S
Molecular Weight:
802.86
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.9881
SMILES:
O.CS(O)(=O)=O.COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
Target:
P-gp

References

Cha YJ, Lee H, Gu N, Kim TE, Lim KS, Yoon SH, Chung JY, Jang IJ, Shin SG, Yu KS, Cho JY. Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants. Basic Clin Pharmacol Toxicol. 2013 Jul 6. Bauer F, Wanek T, Mairinger S, Stanek J, Sauberer M, Kuntner C, Parveen Z, Chiba P, Müller M, Langer O, Erker T. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27. Kim TE, Gu N, Yoon SH, Cho JY, Park KM, Shin SG, Jang IJ, Yu KS. Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies. Clin Ther. 2012 Feb;34(2):482-94.