TargetMol

Fosciclopirox

Product Code:
 
TAR-T9422
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9422-1mg1mg£98.00
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TAR-T9422-2mg2mg£109.00
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TAR-T9422-5mg5mg£135.00
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TAR-T9422-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T9422-10mg10mg£182.00
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TAR-T9422-25mg25mg£303.00
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TAR-T9422-50mg50mg£436.00
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TAR-T9422-100mg100mg£611.00
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TAR-T9422-500mg500mg£1,219.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration.
CAS:
1380539-06-9
Formula:
C13H20NO6P
Molecular Weight:
317.278
Pathway:
Neuroscience; Stem Cells; Proteases/Proteasome
Purity:
0.996
SMILES:
Cc1cc(C2CCCCC2)n(OCOP(O)(O)=O)c(=O)c1
Target:
Gamma-secretase

References

Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the ?-secretase complex. Cell Death Dis. 2021 May 31;12(6):562. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.