TargetMol

SI-113

Product Code:
 
TAR-T9589
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9589-1mg1mg£101.00
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TAR-T9589-2mg2mg£114.00
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TAR-T9589-5mg5mg£142.00
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TAR-T9589-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T9589-10mg10mg£185.00
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TAR-T9589-25mg25mg£282.00
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TAR-T9589-50mg50mg£386.00
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TAR-T9589-100mg100mg£533.00
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Further Information

Bioactivity:
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
CAS:
1392816-46-4
Formula:
C23H24N6O
Molecular Weight:
400.48
Pathway:
Metabolism
Purity:
0.9881
SMILES:
OCCNc1nc(NCCc2ccccc2)c(cnn2C=Cc3ccccc3)c2n1
Target:
SGK

References

Matteoni S, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. Talarico C, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016 Mar 29;7(13):15868-84.