TargetMol

IC 86621

Product Code:
 
TAR-T9760
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9760-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T9760-5mg5mg£120.00
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TAR-T9760-10mg10mg£138.00
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TAR-T9760-25mg25mg£173.00
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TAR-T9760-50mg50mg£221.00
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TAR-T9760-100mg100mg£291.00
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This product comes from: United States.
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Further Information

Bioactivity:
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 ?M for DNA-PK mediated cellular DSB repair.
CAS:
404009-40-1
Formula:
C12H15NO3
Molecular Weight:
221.25
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9933
SMILES:
O=C(C1=CC=C(C=C1O)N2CCOCC2)C
Target:
DNA-PK

References

Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2(10):415-27. Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35(4):639-45.