TargetMol

A-867744

Product Code:
 
TAR-TQ0117
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0117-2mg2mg£102.00
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TAR-TQ0117-5mg5mg£122.00
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TAR-TQ0117-1mL1 mL * 10 mM (in DMSO)£146.00
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TAR-TQ0117-10mg10mg£148.00
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TAR-TQ0117-25mg25mg£226.00
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TAR-TQ0117-50mg50mg£349.00
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TAR-TQ0117-100mg100mg£487.00
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Further Information

Bioactivity:
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
CAS:
1000279-69-5
Formula:
C20H19ClN2O3S
Molecular Weight:
402.89
Pathway:
Neuroscience; Autophagy
Purity:
0.9566
SMILES:
CCC(=O)c1cc(-c2ccc(Cl)cc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O
Target:
AChR; Autophagy

References

Faghih R, et al. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2009 May 28;52(10):3377-84. Malysz J, et al. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J Pharmacol Exp Ther. 2009 Jul;330(1):257-67.