TargetMol

A 419259 trihydrochloride

Product Code:
 
TAR-TQ0132
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0132-1mg1mg£109.00
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TAR-TQ0132-2mg2mg£125.00
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TAR-TQ0132-5mg5mg£158.00
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TAR-TQ0132-10mg10mg£214.00
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TAR-TQ0132-25mg25mg£340.00
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TAR-TQ0132-50mg50mg£542.00
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TAR-TQ0132-100mg100mg£744.00
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TAR-TQ0132-500mg500mg£1,412.00
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Further Information

Bioactivity:
A 419259 trihydrochloride is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
CAS:
1435934-25-0
Formula:
C29H37Cl3N6O
Molecular Weight:
592.01
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
Cl.Cl.Cl.[H][C@@]1(CC[C@@]([H])(CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)N1CCN(C)CC1
Target:
Src

References

Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88. Pene-Dumitrescu T, et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.Oncogene. 2008 Nov 27;27(56):7055-69.