TargetMol

A-484954

Product Code:
 
TAR-TQ0137
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0137-1mg1mg£99.00
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TAR-TQ0137-2mg2mg£111.00
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TAR-TQ0137-5mg5mg£135.00
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TAR-TQ0137-1mL1 mL * 10 mM (in DMSO)£155.00
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TAR-TQ0137-10mg10mg£189.00
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TAR-TQ0137-25mg25mg£329.00
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TAR-TQ0137-50mg50mg£530.00
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TAR-TQ0137-100mg100mg£725.00
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Further Information

Bioactivity:
A 484954 is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
CAS:
142557-61-7
Formula:
C13H15N5O3
Molecular Weight:
289.295
Pathway:
Neuroscience; Microbiology/Virology; Autophagy
Purity:
0.9747
SMILES:
CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Target:
CaMK; Parasite; Autophagy

References

Kodama T, et al. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci. 2018 May;137(1):86-92. Kameshima S, et al. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol Heart Circ Physiol. 2015 May 15;308(10):H1298-305. Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8. Piserchio A, Isiorho E A, Dalby K N, et al.Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.Journal of Biological Chemistry.2023: 104813.