TargetMol

(S)-(-)-Bay-K-8644

Product Code:
 
TAR-TQ0144
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0144-1mg1mg£124.00
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TAR-TQ0144-2mg2mg£146.00
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TAR-TQ0144-5mg5mg£187.00
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TAR-TQ0144-1mL1 mL * 10 mM (in DMSO)£198.00
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TAR-TQ0144-10mg10mg£227.00
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TAR-TQ0144-25mg25mg£410.00
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TAR-TQ0144-50mg50mg£589.00
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Further Information

Bioactivity:
(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.
CAS:
98625-26-4
Formula:
C16H15F3N2O4
Molecular Weight:
356.301
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
COC(=O)C1=C(C)NC(C)=C([C@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
Target:
Calcium Channel

References

Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.