TargetMol

Tesevatinib

Product Code:
 
TAR-TQ0166
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0166-1mg1mg£158.00
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TAR-TQ0166-2mg2mg£197.00
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TAR-TQ0166-5mg5mg£270.00
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TAR-TQ0166-1mL1 mL * 10 mM (in DMSO)£287.00
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TAR-TQ0166-10mg10mg£458.00
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TAR-TQ0166-25mg25mg£704.00
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TAR-TQ0166-50mg50mg£938.00
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Further Information

Bioactivity:
Tesevatinib is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4).
CAS:
781613-23-8
Formula:
C24H25Cl2FN4O2
Molecular Weight:
491.39
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9789
SMILES:
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@H]1C[C@H]2CN(C)C[C@H]2C1
Target:
EGFR; VEGFR; FLT; Ephrin Receptor

References

Gendreau SB, et al. Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.