TargetMol

Zimlovisertib

Product Code:
 
TAR-TQ0167
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0167-2mg2mg£102.00
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TAR-TQ0167-5mg5mg£120.00
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TAR-TQ0167-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-TQ0167-10mg10mg£164.00
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TAR-TQ0167-25mg25mg£259.00
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TAR-TQ0167-50mg50mg£436.00
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TAR-TQ0167-100mg100mg£777.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF06650833 is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay).
CAS:
1817626-54-2
Formula:
C18H20FN3O4
Molecular Weight:
361.373
Pathway:
Immunology/Inflammation; NF-κb
Purity:
0.9801
SMILES:
CC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Target:
IRAK

References

Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542.