TargetMol

Pralsetinib

Product Code:
 
TAR-TQ0277
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0277-1mg1mg£99.00
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TAR-TQ0277-2mg2mg£111.00
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TAR-TQ0277-5mg5mg£155.00
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TAR-TQ0277-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-TQ0277-10mg10mg£189.00
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TAR-TQ0277-25mg25mg£309.00
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TAR-TQ0277-50mg50mg£519.00
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TAR-TQ0277-100mg100mg£701.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion).
CAS:
2097132-94-8
Formula:
C27H32FN9O2
Molecular Weight:
533.612
Pathway:
Apoptosis; Tyrosine Kinase/Adaptors
Purity:
0.9788
SMILES:
COC1(CCC(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Target:
c-RET

References

Subbiah V, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. American Association for Cancer Research. 10.1158/2159-8290.CD-18-0338.