TargetMol

RS102895

Product Code:
 
TAR-TQ0283
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-TQ0283-2mg2mg£100.00
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TAR-TQ0283-5mg5mg£118.00
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TAR-TQ0283-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-TQ0283-10mg10mg£148.00
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TAR-TQ0283-25mg25mg£213.00
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TAR-TQ0283-50mg50mg£286.00
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Quantity:
TAR-TQ0283-100mg100mg£390.00
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This product comes from: United States.
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Further Information

Bioactivity:
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
CAS:
300815-41-2
Formula:
C21H21F3N2O2
Molecular Weight:
390.406
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.9954
SMILES:
FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc2ccccc32)cc1
Target:
CCR

References

Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71. Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57. Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6.