TargetMol

MK-0557

Product Code:
 
TAR-TQ0286
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0286-1mg1mg£116.00
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TAR-TQ0286-2mg2mg£136.00
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TAR-TQ0286-5mg5mg£179.00
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TAR-TQ0286-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-TQ0286-10mg10mg£237.00
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TAR-TQ0286-25mg25mg£385.00
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TAR-TQ0286-50mg50mg£544.00
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TAR-TQ0286-100mg100mg£748.00
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TAR-TQ0286-200mg200mg£1,002.00
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This product comes from: United States.
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Further Information

Bioactivity:
MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).
CAS:
328232-95-7
Formula:
C22H19FN4O3
Molecular Weight:
406.417
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9981
SMILES:
Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1
Target:
Neuropeptide Y Receptor

References

Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4(4):275-82. Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2738-43.