TargetMol

Fluphenazine free base

Product Code:
 
TAR-T0068L2
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T0068L2-5mg5mg£850.00
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Further Information

Bioactivity:
Flufenazine is an antipsychotic drug. It is used to treat chronic mental illnesses such as schizophrenia. Flufenazine works by blocking postsynaptic dopamine D2 receptors in the limbic system, cortical system, and basal ganglia. This prevents the effects of dopamine, which reduces the hallucinations and delusions associated with schizophrenia.
CAS:
69-23-8
Formula:
C22H26F3N3OS
Molecular Weight:
437.53
Purity:
0.98
SMILES:
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

References

1. Xu F, Xia Y, Feng Z, Lin W, Xue Q, Jiang J, Yu X, Peng C, Luo M, Yang Y, Wei Y, Yu L. Repositioning antipsychotic fluphenazine hydrochloride for treating triple negative breast cancer with brain metastases and lung metastases. Am J Cancer Res. 2019 Mar 1;9(3):459-478. eCollection 2019. PubMed PMID: 30949404; PubMed Central PMCID: PMC6448056. 2. Menilli L, Garc?a-Arg?ez AN, Dalla Via L, Miolo G. The neuroleptic drug fluphenazine induces a significant UVA-mediated cytotoxic effect on three human cancer cell lines through apoptosis. Photochem Photobiol Sci. 2019 Mar 12. doi: 10.1039/c9pp00023b. [Epub ahead of print] PubMed PMID: 30860541. 3. Otr?ba M, Beberok A, Wrze?niok D, Buszman E. In vitro melanogenesis inhibition by fluphenazine and prochlorperazine in normal human melanocytes lightly pigmented. Daru. 2018 Sep;26(1):85-89. doi: 10.1007/s40199-018-0206-4. Epub 2018 Jul 24. PubMed PMID: 30159761; PubMed Central PMCID: PMC6154481. 4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK500732/ PubMed PMID: 29999791.