TargetMol

2',5'-Dideoxyadenosine

Product Code:
 
TAR-T10066
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10066-1mg1mg£97.00
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TAR-T10066-5mg5mg£132.00
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TAR-T10066-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T10066-10mg10mg£168.00
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TAR-T10066-25mg25mg£249.00
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TAR-T10066-50mg50mg£369.00
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TAR-T10066-100mg100mg£546.00
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TAR-T10066-500mg500mg£1,107.00
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Further Information

Bioactivity:
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
CAS:
6698-26-6
Formula:
C10H13N5O2
Molecular Weight:
235.247
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9866
SMILES:
C[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(N)ncnc12
Target:
Adenylyl cyclase; Adrenergic Receptor; AChR

References

1. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53. 2. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8. 3. Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631. 4. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.