TargetMol

(3R,5R)-Rosuvastatin

Product Code:
 
TAR-T10126
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10126-5mg5mg£1,251.00
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TAR-T10126-50mg50mg£2,464.00
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Quantity:
TAR-T10126-100mg100mg£3,283.00
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Further Information

Bioactivity:
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
CAS:
1094100-06-7
Formula:
C22H28FN3O6S
Molecular Weight:
481.54
Purity:
0.98
SMILES:
CC(C)c1nc(nc(-c2ccc(F)cc2)c1C=C[C@H](O)C[C@@H](O)CC(O)=O)N(C)S(C)(=O)=O

References

1. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. 2. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78. 3. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.