TargetMol

A-9758

Product Code:
 
TAR-T10210
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10210-5mg5mg£1,412.00
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TAR-T10210-50mg50mg£2,785.00
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TAR-T10210-100mg100mg£3,765.00
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Further Information

Bioactivity:
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.
CAS:
2055271-22-0
Formula:
C25H23Cl2F3N2O3
Molecular Weight:
527.37
Pathway:
Metabolism
Purity:
0.98
SMILES:
Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CCC(CC4)C(O)=O)c3Cl)cc12)C(F)(F)F
Target:
ROR

References

1. Gauld S, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046.