TargetMol

APX-115 free base

Product Code:
 
TAR-T10353
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10353-1mg1mg£115.00
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TAR-T10353-5mg5mg£172.00
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TAR-T10353-1mL1 mL * 10 mM (in DMSO)£173.00
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TAR-T10353-10mg10mg£230.00
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TAR-T10353-25mg25mg£389.00
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TAR-T10353-50mg50mg£548.00
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TAR-T10353-100mg100mg£766.00
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This product comes from: United States.
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Further Information

Bioactivity:
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase ?Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
CAS:
1270084-92-8
Formula:
C17H17N3O
Molecular Weight:
279.343
Pathway:
Immunology/Inflammation; Metabolism
Purity:
0.9903
SMILES:
CCCc1c([nH]n(-c2ccccn2)c1=O)-c1ccccc1
Target:
NADPH-oxidase; NADPH

References

1. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. 2. Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.