TargetMol

APX-115

Product Code:
 
TAR-T10354
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10354-1mg1mg£111.00
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TAR-T10354-5mg5mg£168.00
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TAR-T10354-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T10354-10mg10mg£229.00
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TAR-T10354-25mg25mg£402.00
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TAR-T10354-50mg50mg£567.00
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TAR-T10354-100mg100mg£777.00
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TAR-T10354-500mg500mg£1,508.00
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Further Information

Bioactivity:
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase ?Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
CAS:
1395946-75-4
Formula:
C17H18ClN3O
Molecular Weight:
315.8
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
Cl.CCCc1c(O)n(nc1-c1ccccc1)-c1ccccn1
Target:
NADPH-oxidase

References

Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.