TargetMol

Avibactam free acid

Product Code:
 
TAR-T10422
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10422-5mg5mg£116.00
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This product comes from: United States.
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Further Information

Bioactivity:
Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15).
CAS:
1192500-31-4
Formula:
C7H11N3O6S
Molecular Weight:
265.24
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
[H][C@]12CN([C@@H](CC1)C(N)=O)C(=O)N2OS(O)(=O)=O
Target:
Antibacterial

References

1. Ehmann DE, et al. Avibactam is a covalent, reversible, non-?-lactam ?-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8. 2. Livermore DM, et al. Characterization of ?-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8. 3. Berkhout J, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.