TargetMol

AZ12601011

Product Code:
 
TAR-T10426
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10426-50mg50mg£1,099.00
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TAR-T10426-100mg100mg£1,500.00
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Further Information

Bioactivity:
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting TGFBR1, ALK4, and ALK7.
CAS:
T10426
Formula:
C19H15N5
Molecular Weight:
313.36
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1
Target:
ALK

References

1. Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ?Superfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95(2):222-234.