TargetMol

BACE1-IN-1

Product Code:
 
TAR-T10450
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10450-5mg5mg£404.00
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Quantity:
TAR-T10450-50mg50mg£1,797.00
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Quantity:
TAR-T10450-100mg100mg£2,560.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
CAS:
1310347-50-2
Formula:
C18H14F3N5O2
Molecular Weight:
389.338
Pathway:
Neuroscience
Purity:
0.98
SMILES:
C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Target:
BACE

References

1. Hilpert H, et al. ?-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95.