TargetMol

BCR-ABL-IN-2

Product Code:
 
TAR-T10489
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10489-5mg5mg£850.00
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Quantity:
TAR-T10489-50mg50mg£1,661.00
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Quantity:
TAR-T10489-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).
CAS:
897369-18-5
Formula:
C24H25Cl2N5O3
Molecular Weight:
502.4
Purity:
0.98
SMILES:
CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(n1)-c1ccc2CN[C@@H](Cc2c1)C(O)=O

References

1. Chan WW, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell. 2011 Apr 12;19(4):556-68. 2. ARYL SULFONOHYDRAZIDES. US 2008/0113967 A1.