TargetMol

BPH-1358 free base

Product Code:
 
TAR-T10586
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10586-5mg5mg£850.00
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Quantity:
TAR-T10586-50mg50mg£1,661.00
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Quantity:
TAR-T10586-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
CAS:
801985-13-7
Formula:
C32H28N6O2
Molecular Weight:
528.616
Purity:
0.98
SMILES:
O=C(Nc1cccc(c1)C1=NCCN1)c1ccc(cc1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C1=NCCN1

References

1. Zhu W, et al. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12;58(3):1215-27. 2. Liu YL, et al. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett. 2015 Jan 29;6(3):349-54.