TargetMol

c-Kit-IN-2

Product Code:
 
TAR-T10650
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10650-5mg5mg£930.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10650-50mg50mg£1,821.00
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Quantity:
TAR-T10650-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (GI50s: 1, 3, and 2 nM).
CAS:
2121515-37-3
Formula:
C25H29N9O2S
Molecular Weight:
519.63
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Target:
c-Kit

References

1. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.