TargetMol

CCR4 antagonist 2

Product Code:
 
TAR-T10713
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10713-5mg5mg£1,492.00
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TAR-T10713-50mg50mg£2,946.00
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Quantity:
TAR-T10713-100mg100mg£4,006.00
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Further Information

Bioactivity:
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
CAS:
2206788-99-8
Formula:
C26H28Cl2N6O
Molecular Weight:
511.45
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.98
SMILES:
C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CO
Target:
Calcium Channel

References

1. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.