TargetMol

CCT241533

Product Code:
 
TAR-T10718
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10718-5mg5mg£850.00
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Quantity:
TAR-T10718-50mg50mg£1,661.00
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Quantity:
TAR-T10718-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
CAS:
1262849-73-9
Formula:
C23H27FN4O4
Molecular Weight:
442.491
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O
Target:
Chk

References

1. Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72. 2. Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.