TargetMol

SEL120-34A monohydrochloride

Product Code:
 
TAR-T10744L2
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
SEL120-34A monohydrochloride is an ATP-competitive and selective inhibitor of CDK8(CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8),has anti-tumor activity.
CAS:
T10744L2
Formula:
C15H19Br2ClN4
Molecular Weight:
450.6
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl
Target:
CDK

References

1. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.