TargetMol

Celgosivir

Product Code:
 
TAR-T10755L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T10755L-1mg1mg£174.00
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TAR-T10755L-2mg2mg£230.00
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TAR-T10755L-5mg5mg£306.00
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TAR-T10755L-10mg10mg£406.00
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TAR-T10755L-25mg25mg£629.00
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TAR-T10755L-50mg50mg£864.00
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TAR-T10755L-100mg100mg£1,139.00
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TAR-T10755L-500mg500mg£2,215.00
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This product comes from: United States.
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Further Information

Bioactivity:
Celgosivir is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ).
CAS:
121104-96-9
Formula:
C12H21NO5
Molecular Weight:
259.3
Pathway:
Metabolism
Purity:
0.98
SMILES:
O[C@@H]1[C@@]2(N(C[C@H](OC(CCC)=O)[C@H]1O)CC[C@@H]2O)[H]
Target:
Glucosidase

References

Watanabe S, et al. Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res. 2012 Oct;96(1):32-5. Rathore AP, et al. Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes andprotects against lethal challenge mouse model. Antiviral Res. 2011 Dec;92(3):453-60. Whitby K, et al. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir Chem Chemother. 2004 May;15(3):141-51. Taylor DL, et al. Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoylcastanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells. Antimicrob Agents Chemother. 1994 Aug;38(8):1780-7.