TargetMol

CFTR corrector 4

Product Code:
 
TAR-T10776
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10776-1mg1mg£125.00
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Quantity:
TAR-T10776-5mg5mg£213.00
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TAR-T10776-1mL1 mL * 10 mM (in DMSO)£242.00
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TAR-T10776-10mg10mg£294.00
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TAR-T10776-25mg25mg£523.00
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Quantity:
TAR-T10776-50mg50mg£707.00
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Quantity:
TAR-T10776-100mg100mg£978.00
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Quantity:
TAR-T10776-500mg500mg£1,886.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CFTR corrector 4 is a highly potent and orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR). It can increase CFTR levels at the cell surface and have the potential for the treatment of cystic fibrosis.
CAS:
1918142-34-3
Formula:
C29H27F2NO7
Molecular Weight:
539.532
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
COc1ccc2[C@@H](C[C@@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
Target:
CFTR

References

1. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.