TargetMol

DC0-NH2

Product Code:
 
TAR-T10968
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10968-5mg5mg£724.00
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Quantity:
TAR-T10968-50mg50mg£1,661.00
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Quantity:
TAR-T10968-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then adenine residue is alkylated by its propabenzindole (CBI) component.
CAS:
615538-51-7
Formula:
C31H24ClN5O3
Molecular Weight:
550.02
Purity:
0.98
SMILES:
Nc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc2[nH]c(cc2c1)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21

References

1. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.