TargetMol

Dot1L-IN-1

Product Code:
 
TAR-T11081
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11081-5mg5mg£1,492.00
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Quantity:
TAR-T11081-50mg50mg£2,946.00
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Quantity:
TAR-T11081-100mg100mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
CAS:
2088518-50-5
Formula:
C32H36ClN9O2S
Molecular Weight:
646.21
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CN(CCCNC(=O)CNC(=O)Nc1ccc2sc(Cl)c(-c3cccnc3C)c2c1)[C@@H]1CCCN(C1)c1ncnc2[nH]ccc12
Target:
Histone Methyltransferase

References

1. M?bitz H, et al. Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Med Chem Lett. 2017 Feb 14;8(3):338-343.