TargetMol

Duocarmycin SA

Product Code:
 
TAR-T11118
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11118-5mg5mgEnquire
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Further Information

Bioactivity:
Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA.Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.
CAS:
130288-24-3
Formula:
C25H23N3O7
Molecular Weight:
477.473
Purity:
0.98
SMILES:
[H][C@]12C[C@@]11C(=CC(=O)c3[nH]c(cc13)C(=O)OC)N(C2)C(=O)c1cc2cc(OC)c(OC)c(OC)c2[nH]1

References

1. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. 2. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.