TargetMol

Duocarmycin DM free base

Product Code:
 
TAR-T11119
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11119-5mg5mg£655.00
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TAR-T11119-50mg50mg£2,303.00
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Quantity:
TAR-T11119-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug?antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
CAS:
1116745-06-2
Formula:
C26H26ClN3O3
Molecular Weight:
463.96
Purity:
0.98
SMILES:
CN(C)CCOc1ccc2[nH]c(cc2c1)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21

References

1. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.