TargetMol

DYRKs-IN-1

Product Code:
 
TAR-T11132
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11132-5mg5mg£1,572.00
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TAR-T11132-50mg50mg£3,107.00
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Quantity:
TAR-T11132-100mg100mg£4,247.00
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This product comes from: United States.
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Further Information

Bioactivity:
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively.
CAS:
1387090-01-8
Formula:
C30H30ClN7O4
Molecular Weight:
588.07
Pathway:
Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(nc3[nH]c2=O)N2CC3CCC(C2)O3)c1)c1ccccc1
Target:
DYRK

References

1. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1 2. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.