TargetMol

(E)-GABAB receptor antagonist 1

Product Code:
 
TAR-T11137
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11137-1mg1mg£227.00
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TAR-T11137-2mg2mg£306.00
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TAR-T11137-1mL1 mL * 10 mM (in DMSO)£417.00
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TAR-T11137-5mg5mg£430.00
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TAR-T11137-10mg10mg£600.00
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TAR-T11137-25mg25mg£863.00
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TAR-T11137-50mg50mg£1,179.00
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TAR-T11137-100mg100mg£1,589.00
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TAR-T11137-500mg500mg£3,115.00
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Further Information

Bioactivity:
(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM. GABAB receptor antagonist 1 is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.
CAS:
1611483-29-4
Formula:
C18H24O4
Molecular Weight:
304.38
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
C(=C/C(C(O)=O)=O)C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
Target:
GABA Receptor

References

1. Chen LH, et al. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5(7):742-7.