TargetMol

EG01377

Product Code:
 
TAR-T11154
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11154-5mg5mg£1,091.00
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TAR-T11154-50mg50mg£2,143.00
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TAR-T11154-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.
CAS:
2227996-00-9
Formula:
C26H30N6O6S2
Molecular Weight:
586.68
Purity:
0.98
SMILES:
NCc1ccc(cc1)-c1cc2CCOc2c(c1)S(=O)(=O)Nc1ccsc1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O

References

1. Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF?) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61(9):4135-4154.