TargetMol

FR194738 free base

Product Code:
 
TAR-T11321
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11321-1mg1mg£258.00
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TAR-T11321-5mg5mg£470.00
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TAR-T11321-1mL1 mL * 10 mM (in DMSO)£510.00
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TAR-T11321-10mg10mg£651.00
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TAR-T11321-25mg25mg£978.00
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TAR-T11321-50mg50mg£1,291.00
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Quantity:
TAR-T11321-100mg100mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.?
CAS:
204067-45-8
Formula:
C27H37NO2S
Molecular Weight:
439.65
Pathway:
Microbiology/Virology
Purity:
0.9965
SMILES:
C(N(C/C=C/C#CC(C)(C)C)CC)C1=CC(OCC(OCC=2C=CSC2)(C)C)=CC=C1
Target:
Antifungal

References

1. Sawada M, et al. Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. Eur J Pharmacol. 2001 Nov 9;431(1):11-6. 2. Sawada M, et al. Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. 3. Sawada M, et al. Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters. Biol Pharm Bull. 2002 Dec;25(12):1577-82.