TargetMol

FR 167653

Product Code:
 
TAR-T11327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11327-5mg5mg£483.00
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  • Further Information
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Further Information

Bioactivity:
FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
CAS:
158876-66-5
Formula:
C24H20FN5O6S
Molecular Weight:
525.51
Pathway:
MAPK
Purity:
0.98
SMILES:
OS(O)(=O)=O.Fc1ccc(cc1)-c1nn2CCN(Nc2c1-c1ccncc1)C(=O)C(=O)c1ccccc1
Target:
p38 MAPK

References

1. Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. 2. Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. 3. Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74.