TargetMol

G-5555 hydrochloride (1648863-90-4 free base)

Product Code:
 
TAR-T11342
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11342-100mg100mgEnquire
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TAR-T11342-50mg50mgEnquire
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TAR-T11342-5mg5mg£186.00
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TAR-T11342-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-T11342-10mg10mg£257.00
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TAR-T11342-25mg25mg£468.00
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Further Information

Bioactivity:
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
CAS:
T11342
Formula:
C25H26Cl2N6O3
Molecular Weight:
529.42
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O.[H]Cl
Target:
PAK

References

1. Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. 2. Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.