TargetMol

Gefitinib N-oxide

Product Code:
 
TAR-T11385
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11385-5mg5mg£850.00
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Quantity:
TAR-T11385-50mg50mg£1,661.00
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Quantity:
TAR-T11385-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.
CAS:
847949-51-3
Formula:
C22H24ClFN4O4
Molecular Weight:
462.91
Purity:
0.98
SMILES:
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCC[N+]1([O-])CCOCC1

References

1. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. 2. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.