TargetMol

Glutaminyl Cyclase Inhibitor 3

Product Code:
 
TAR-T11422
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11422-5mg5mg£1,010.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T11422-50mg50mg£1,982.00
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Quantity:
TAR-T11422-100mg100mg£2,560.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer?s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.
CAS:
2092921-50-9
Formula:
C24H32N6O2S
Molecular Weight:
468.62
Purity:
0.98
SMILES:
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1

References

1. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.