TargetMol

GNE-616

Product Code:
 
TAR-T11439
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11439-5mg5mg£1,733.00
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Quantity:
TAR-T11439-50mg50mg£3,428.00
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Quantity:
TAR-T11439-100mg100mg£4,729.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain.
CAS:
2349371-81-7
Formula:
C24H23F4N5O3S
Molecular Weight:
537.53
Purity:
0.98
SMILES:
Fc1cc2[C@H](CCOc2cc1S(=O)(=O)Nc1ccncn1)N1CC[C@@H](C[C@@H]1c1ccccn1)C(F)(F)F

References

1. McKerrall SJ, et al. Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain. J Med Chem. 2019 Apr 25;62(8):4091-4109.