TargetMol

HG-12-6

Product Code:
 
TAR-T11559
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11559-5mg5mg£1,332.00
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Quantity:
TAR-T11559-50mg50mg£2,625.00
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Quantity:
TAR-T11559-100mg100mg£3,524.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM). HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
CAS:
2222354-57-4
Formula:
C29H27F3N6O2S
Molecular Weight:
580.63
Purity:
0.98
SMILES:
FC(F)(F)c1cc(NC(=O)c2cccc(c2)-c2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1CN1CCNCC1

References

1. Wang L, et al. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J Biol Chem. 2019 Mar 22;294(12):4511-4519.