TargetMol

HL271

Product Code:
 
TAR-T11570
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11570-5mg5mg£850.00
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Quantity:
TAR-T11570-50mg50mg£1,661.00
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Quantity:
TAR-T11570-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
CAS:
1422365-52-3
Formula:
C13H17ClF3N5O
Molecular Weight:
351.76
Pathway:
Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Cl.FC(F)(F)Oc1ccc(NC(=N)NC(=N)N2CCCC2)cc1
Target:
AMPK

References

1. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9. 2. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.